A special Call for Proposals is now open for any work that will actively contribute to finding COVID-related treatments or vaccines, or improve conditions for frontline workers, including developing sensors and diagnostic tools or special surfaces with antiviral properties. The deadline for proposals is Thursday, May 21, and we will respond within two weeks.
Together with IT group at CLS we have enabled remote access to one of our reconstruction servers. Users can obtain remote access to 5-10 data sets at a time, reconstruct data, and use Avizo for visualization and data analysis directly on BMIT server. Please contact Dr. Adam Webb (email@example.com) for details and scheduling. Depending on the number of requests access duration may be limited to 2-3 days.
Ever since early humans discovered how to grind grain, the art of breadmaking has flourished and today bread is the most widely consumed food in the world. The apron has now been replaced by the lab coat as scientists seek to understand the intricacies of creating healthier, more consistent commercial bread products that meet changing consumer demands.
Sun, Xinyang, Martin G. Scanlon, Reine-Marie Guillermic, et al. "The effects of sodium reduction on the gas phase of bread doughs using synchrotron X-ray microtomography." Food Research International (2019)
Based on spectral K-edge subtraction imaging (developed at CLS-BMIT), a new energy dispersive X-ray absorption spectroscopy method is developed at BMIT-BM beamline for simultaneous wide-field imaging and transmission X-ray Absorption Spectroscopy (XAS). Sufficient energy and spatial resolution are demonstrated for both full field imaging and computed tomography in quantifying selenium chemical species.
- CT Data Processing Using UFO-KIT and Dragonfly (May 20-22, 2020) - 10X magnification capability is now available - Cycle 32 Call for Proposals - Important Notes for Preparation of Proposals - Around the Beamlines - Pictures of the Season - Upcoming Conferences
Synchrotron 3D computed tomography (CT) at BMIT-ID beamline at Canadian Light Source was used to explain the features of the HIC cracks formation during tensile tests.
We developed the synchrotron-based x-ray inline phase contrast imaging-computed tomography (SR-inline-PCI-CT) at the Biomedical Imaging and Therapy (BMIT) Facility of Canadian Light Source to visualize the printed hydrogel-based scaffolds.
A 60 million-year-old salamander fossil was imaged (inside rock) at BMIT ID beamline at 80keV X-ray energy.
COVID-related research at BMIT
Apply for COVID-19 special beamtime (deadline May 21): www.lightsource.ca/covid19_call_for_proposals
BMIT is among beamlines that can help scientific community in the battle against COVID-19. In particular:
- X-ray microtomography can be employed to reveal 3D microarchitecture of lung samples, for instance, detecting inflammation, blood clots and structural damage in the lungs of COVID positive cases. In a sub-centimeter specimen spatial resolution can be as good as 2-3 microns which is the size of small alveoli and air-ways.
- Analyzer-crystal based imaging (e.g., DEI, MIR) can be used to probe microstructure of lungs in a “statistical” sense by means of collecting ultra-small angle scattering signal (USAXS) from airways. This technique in radiography mode could be a fast method to detect inflammation in the lungs and potentially be used to assess efficacy of potential treatment(s) by observing relative changes in the USAXS signal in treatment groups. Owing to a very small radiation dose, this method can be utilized to image the same animal at multiple time points after commencing treatment.
IMPORTANT: Please note that possibility of carrying out experiments will require approval of the CLS health and safety group and may be affected at any time by rapidly evolving health situation in Saskatchewan and Canada. Please contact Dr. Sergey Gasilov (firstname.lastname@example.org) for details.
The BMIT facility at the Canadian Light Source is specifically designed to support a wide variety of programs in the life sciences, and provides outstanding possibilities for research, including potential clinical applications in imaging and radiation therapy. The facility has two beamlines; a bend magnet beamline, 05B1-1, and an insertion device beamline, 05ID-2. The BMIT advanced imaging modalities allow biomedical systems to be visualized in ways not possible using conventional clinical systems. These can provide insight into anatomy, function, visualization of disease processes including therapeutic response and the possibility of repeated imaging at low dose.
- Nordström; Charlotta Kämpfe; Li; Hao; Ladak et al. (2020). A Micro-CT and Synchrotron Imaging Study of the Human Endolymphatic Du .... Scientific Reports 10(8295) . 10.1038/s41598-020-65110-0.
- Eifert; L.; Bevilacqua; N.; Köble et al. (2020). Synchrotron X-ray Radiography and Tomography of Vanadium Redox Flow Ba .... ChemSusChem . 10.1002/cssc.202000541.
- Mei; Xueshuang; Glueckert; Rudolf; Schrott-Fischer et al. (2020). Vascular Supply of the Human Spiral Ganglion: Novel Three-Dimensional .... Scientific Reports 10(1) , 5877. 10.1038/s41598-020-62653-0.